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Table 2 Spectrum of mutations in all residues in the studied proteinsa

From: Spectrum of disease-causing mutations in protein secondary structures

Amino acid Original residues Expected residues χ2 P value Mutant residues Expected residues χ2 P value
A 169 161 0.43 5.14E-01 83 148 28.28*** 1.05E-07
C 79 38 43.38*** 4.51E-11 133 86 25.54*** 4.34E-07
D 98 131 8.28** 4.00E-03 155 98 32.54*** 1.16E-08
E 113 168 17.82*** 2.43E-05 84 86 0.05 8.20E-01
F 66 104 13.66*** 2.19E-04 90 98 0.72 3.97E-01
G 246 167 37.28*** 1.02E-09 106 141 8.89** 2.87E-03
H 87 61 10.74*** 1.05E-03 108 98 0.93 3.34E-01
I 99 126 5.76* 1.64E-02 80 129 18.71*** 1.52E-05
K 56 140 50.05*** 1.50E-12 109 86 6.09* 1.36E-02
L 231 239 0.29 5.89E-01 113 203 39.88*** 2.70E-10
M 78 58 7.00** 8.15E-03 97 55 31.33*** 2.18E-08
N 90 92 0.03 8.58E-01 74 98 6.05** 1.39E-02
P 94 122 6.54** 1.05E-02 194 148 14.58*** 1.35E-04
Q 62 102 15.50*** 8.24E-05 115 86 9.69** 1.85E-03
R 348 142 299.39*** 4.48E-67 222 209 0.79 3.73E-01
S 125 146 2.95 8.58E-02 174 228 12.61*** 3.84E-04
T 84 123 12.50*** 4.08E-04 136 148 0.91 3.39E-01
V 147 168 2.73 9.88E-02 185 148 9.47** 2.09E-03
W 55 37 9.34** 2.24E-03 77 43 26.77*** 2.30E-07
Y 84 87 0.11 7.40E-01 76 74 0.07 7.98E-01
Sum 2411 2411    2411 2411   
  1. aχ2-numbers in italics indicate underrepresentation and numbers in bold overrepresentation compared to random distribution based on amino acid frequencies. The results of the χ2 are shown with significance level: * P < 0.05; ** P < 0.01; *** P < 0.001.