Spectrum of disease-causing mutations in protein secondary structures

BMC Structural Biology

Table 2 Spectrum of mutations in all residues in the studied proteins^a

Amino acid	Original residues	Expected residues	χ²	P value	Mutant residues	Expected residues	χ²	P value
A	169	161	0.43	5.14E-01	83	148	28.28***	1.05E-07
C	79	38	43.38***	4.51E-11	133	86	25.54***	4.34E-07
D	98	131	8.28**	4.00E-03	155	98	32.54***	1.16E-08
E	113	168	17.82***	2.43E-05	84	86	0.05	8.20E-01
F	66	104	13.66***	2.19E-04	90	98	0.72	3.97E-01
G	246	167	37.28***	1.02E-09	106	141	8.89**	2.87E-03
H	87	61	10.74***	1.05E-03	108	98	0.93	3.34E-01
I	99	126	5.76*	1.64E-02	80	129	18.71***	1.52E-05
K	56	140	50.05***	1.50E-12	109	86	6.09*	1.36E-02
L	231	239	0.29	5.89E-01	113	203	39.88***	2.70E-10
M	78	58	7.00**	8.15E-03	97	55	31.33***	2.18E-08
N	90	92	0.03	8.58E-01	74	98	6.05**	1.39E-02
P	94	122	6.54**	1.05E-02	194	148	14.58***	1.35E-04
Q	62	102	15.50***	8.24E-05	115	86	9.69**	1.85E-03
R	348	142	299.39***	4.48E-67	222	209	0.79	3.73E-01
S	125	146	2.95	8.58E-02	174	228	12.61***	3.84E-04
T	84	123	12.50***	4.08E-04	136	148	0.91	3.39E-01
V	147	168	2.73	9.88E-02	185	148	9.47**	2.09E-03
W	55	37	9.34**	2.24E-03	77	43	26.77***	2.30E-07
Y	84	87	0.11	7.40E-01	76	74	0.07	7.98E-01
Sum	2411	2411			2411	2411

^aχ²-numbers in italics indicate underrepresentation and numbers in bold overrepresentation compared to random distribution based on amino acid frequencies. The results of the χ² are shown with significance level: * P < 0.05; ** P < 0.01; *** P < 0.001.

ISSN: 1472-6807