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Table 5 Spectrum of mutations in α-helicesa

From: Spectrum of disease-causing mutations in protein secondary structures

Amino acid Original residues Expected residues χ2 P value Mutant residues Expected residues χ2 P value
A 89 83 0.45 5.03E-01 23 57 20.13*** 7.25E-06
C 26 14 11.27*** 7.88E-04 56 33 15.76*** 7.18E-05
D 34 44 2.23 1.35E-01 59 38 11.78*** 5.99E-04
E 61 96 12.71*** 3.64E-04 26 33 1.54 2.15E-01
F 28 36 1.76 1.84E-01 37 38 0.02 8.87E-01
G 48 30 10.69*** 1.08E-03 46 54 1.31 2.52E-01
H 23 21 0.13 7.19E-01 41 38 0.26 6.12E-01
I 41 51 1.96 1.61E-01 29 50 8.63** 3.30E-03
K 20 61 27.70*** 1.41E-07 52 33 10.73*** 1.05E-03
L 101 112 1.04 3.09E-01 49 78 10.86*** 9.85E-04
M 41 29 5.11* 2.37E-02 24 21 0.34 5.59E-01
N 22 27 1.08 3.00E-01 29 38 2.08 1.49E-01
P 29 24 1.15 2.84E-01 90 57 19.38*** 1.07E-05
Q 28 45 6.12* 1.34E-02 55 33 14.41*** 1.47E-04
R 153 64 122.78*** 1.56E-28 73 80 0.70 4.04E-01
S 36 46 2.22 1.36E-01 53 88 13.66*** 2.19E-04
T 30 38 1.84 1.75E-01 61 57 0.31 5.79E-01
V 62 59 0.18 6.69E-01 69 57 2.61 1.06E-01
W 24 16 4.19* 4.06E-02 32 17 14.36*** 1.51E-04
Y 32 33 0.01 9.29E-01 24 28 0.68 4.08E-01
Sum 928 928    928 928   
  1. aχ2-numbers in italics indicate underrepresentation and numbers in bold overrepresentation compared to random distribution based on amino acid frequencies. The results of the χ2 are shown with significance level: * P < 0.05; ** P < 0.01; *** P < 0.001.