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Table 6 Spectrum of mutations in β-strandsa

From: Spectrum of disease-causing mutations in protein secondary structures

Amino acid Original residues Expected residues χ2 P value Mutant residues Expected residues χ2 P value
A 39 33 0.93 3.34E-01 14 34 11.49*** 6.98E-04
C 19 12 4.58* 3.24E-02 39 20 19.08*** 1.26E-05
D 17 15 0.22 6.38E-01 26 22 0.56 4.54E-01
E 21 25 0.64 4.23E-01 20 20 0.01 9.36E-01
F 15 36 12.66*** 3.75E-04 24 22 0.11 7.43E-01
G 44 27 10.61*** 1.13E-03 27 32 0.86 3.54E-01
H 23 13 8.33** 3.90E-03 32 22 4.06* 4.38E-02
I 34 49 4.80* 2.84E-02 16 29 6.15** 1.31E-02
K 13 23 4.60* 3.20E-02 23 20 0.57 4.49E-01
L 63 66 0.10 7.48E-01 27 46 8.05** 4.56E-03
M 14 13 0.03 8.53E-01 16 13 0.90 3.43E-01
N 19 14 1.67 1.97E-01 20 22 0.27 6.05E-01
P 15 11 1.08 2.99E-01 47 34 5.27* 2.16E-02
Q 10 16 2.24 1.34E-01 20 20 0.01 9.36E-01
R 77 29 80.03*** 3.69E-19 60 48 3.17 7.50E-02
S 15 23 2.88 8.98E-02 55 52 0.18 6.68E-01
T 16 35 10.20*** 1.41E-03 36 34 0.16 6.88E-01
V 53 71 4.44* 3.51E-02 27 34 1.32 2.50E-01
W 16 10 3.23 7.25E-02 8 10 0.34 5.61E-01
Y 27 27 0.00 9.60E-01 13 17 0.87 3.50E-01
Sum 550 550    550 550   
  1. aχ2-numbers in italics indicate underrepresentation and numbers in bold overrepresentation compared to random distribution based on amino acid frequencies. The results of the χ2 are shown with significance level: * P < 0.05; ** P < 0.01; *** P < 0.001.