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Table 7 Spectrum of mutations in turns and bendsa

From: Spectrum of disease-causing mutations in protein secondary structures

Amino acid Original residues Expected residues χ2 P value Mutant residues Expected residues χ2 P value
A 20 24 0.79 3.73E-01 21 28 1.85 1.74E-01
C 9 7 0.97 3.26E-01 22 16 1.86 1.72E-01
D 30 35 0.70 4.04E-01 27 19 3.56 5.92E-02
E 14 27 6.28** 1.22E-02 25 16 4.43* 3.54E-02
F 10 16 2.13 1.45E-01 16 19 0.42 5.16E-01
G 128 72 43.23*** 4.87E-11 22 27 0.94 3.32E-01
H 17 13 1.12 2.91E-01 18 19 0.04 8.51E-01
I 8 12 1.20 2.73E-01 10 25 8.75** 3.10E-03
K 10 28 11.80*** 5.92E-04 17 16 0.02 8.95E-01
L 24 30 1.27 2.60E-01 20 39 9.12** 2.53E-03
M 10 8 0.67 4.13E-01 8 11 0.63 4.27E-01
N 19 26 1.72 1.90E-01 12 19 2.47 1.16E-01
P 24 29 1.02 3.12E-01 33 28 0.81 3.69E-01
Q 7 21 9.71** 1.84E-03 14 16 0.37 5.44E-01
R 69 26 70.17*** 5.44E-17 63 40 13.25*** 2.73E-04
S 27 34 1.27 2.59E-01 36 44 1.30 2.55E-01
T 16 20 0.68 4.09E-01 22 28 1.37 2.41E-01
V 7 17 6.05** 1.39E-02 42 28 6.72** 9.52E-03
W 4 5 0.07 7.92E-01 16 8 7.33** 6.78E-03
Y 8 11 1.02 3.13E-01 17 14 0.59 4.42E-01
Sum 461 461    461 461   
  1. aχ2-numbers in italics indicate underrepresentation and numbers in bold overrepresentation compared to random distribution based on amino acid frequencies. The results of the χ2 are shown with significance level: * P < 0.05; ** P < 0.01; *** P < 0.001.