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Table 8 Mutated and mutant residues not in secondary structuresa

From: Spectrum of disease-causing mutations in protein secondary structures

Amino acid group Original residues Expected residues χ2 P value Mutant residues Expected residues χ2 P value
A 18 22 0.84 3.58E-01 21 29 2.16 1.42E-01
C 12 7 4.51 3.37E-02 25 17 3.93* 4.73E-02
D 46 34 4.20 4.04E-02 17 19 0.27 6.06E-01
E 10 22 6.53** 1.06E-02 17 17 0.00 9.72E-01
F 15 17 0.17 6.83E-01 13 19 2.04 1.53E-01
G 35 32 0.37 5.40E-01 26 28 0.10 7.48E-01
H 27 14 13.05*** 3.04E-04 24 19 1.16 2.81E-01
I 19 17 0.23 6.32E-01 16 25 3.41 6.48E-02
K 11 27 9.15** 2.49E-03 13 17 0.88 3.47E-01
L 29 36 1.36 2.44E-01 43 40 0.27 6.04E-01
M 6 9 0.93 3.36E-01 13 11 0.43 5.11E-01
N 10 23 6.96** 8.34E-03 30 19 5.98** 1.45E-02
P 61 52 1.44 2.29E-01 26 29 0.29 5.90E-01
Q 3 20 13.97*** 1.86E-04 17 17 0.00 9.72E-01
R 53 23 37.42*** 9.51E-10 49 41 1.59 2.08E-01
S 31 40 2.13 1.45E-01 47 45 0.13 7.14E-01
T 24 30 1.25 2.63E-01 22 29 1.65 1.99E-01
V 25 25 0.00 9.44E-01 25 29 0.53 4.68E-01
W 8 6 0.41 5.22E-01 11 8 0.78 3.76E-01
Y 29 17 8.77** 3.06E-03 17 14 0.45 5.02E-01
Sum 472 472    472 472   
  1. aχ2-numbers in italics indicate underrepresentation and numbers in bold overrepresentation compared to random distribution based on amino acid frequencies. The results of the χ2 are shown with significance level: * P < 0.05; ** P < 0.01; *** P < 0.001.