From: Spectrum of disease-causing mutations in protein secondary structures
Amino acid group | Original residues | Expected residues | χ2 | P value | Mutant residues | Expected residues | χ2 | P value |
---|---|---|---|---|---|---|---|---|
A | 18 | 22 | 0.84 | 3.58E-01 | 21 | 29 | 2.16 | 1.42E-01 |
C | 12 | 7 | 4.51 | 3.37E-02 | 25 | 17 | 3.93* | 4.73E-02 |
D | 46 | 34 | 4.20 | 4.04E-02 | 17 | 19 | 0.27 | 6.06E-01 |
E | 10 | 22 | 6.53** | 1.06E-02 | 17 | 17 | 0.00 | 9.72E-01 |
F | 15 | 17 | 0.17 | 6.83E-01 | 13 | 19 | 2.04 | 1.53E-01 |
G | 35 | 32 | 0.37 | 5.40E-01 | 26 | 28 | 0.10 | 7.48E-01 |
H | 27 | 14 | 13.05*** | 3.04E-04 | 24 | 19 | 1.16 | 2.81E-01 |
I | 19 | 17 | 0.23 | 6.32E-01 | 16 | 25 | 3.41 | 6.48E-02 |
K | 11 | 27 | 9.15** | 2.49E-03 | 13 | 17 | 0.88 | 3.47E-01 |
L | 29 | 36 | 1.36 | 2.44E-01 | 43 | 40 | 0.27 | 6.04E-01 |
M | 6 | 9 | 0.93 | 3.36E-01 | 13 | 11 | 0.43 | 5.11E-01 |
N | 10 | 23 | 6.96** | 8.34E-03 | 30 | 19 | 5.98** | 1.45E-02 |
P | 61 | 52 | 1.44 | 2.29E-01 | 26 | 29 | 0.29 | 5.90E-01 |
Q | 3 | 20 | 13.97*** | 1.86E-04 | 17 | 17 | 0.00 | 9.72E-01 |
R | 53 | 23 | 37.42*** | 9.51E-10 | 49 | 41 | 1.59 | 2.08E-01 |
S | 31 | 40 | 2.13 | 1.45E-01 | 47 | 45 | 0.13 | 7.14E-01 |
T | 24 | 30 | 1.25 | 2.63E-01 | 22 | 29 | 1.65 | 1.99E-01 |
V | 25 | 25 | 0.00 | 9.44E-01 | 25 | 29 | 0.53 | 4.68E-01 |
W | 8 | 6 | 0.41 | 5.22E-01 | 11 | 8 | 0.78 | 3.76E-01 |
Y | 29 | 17 | 8.77** | 3.06E-03 | 17 | 14 | 0.45 | 5.02E-01 |
Sum | 472 | 472 | Â | Â | 472 | 472 | Â | Â |