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Table 9 Spectrum of mutations in α-helices in amino acid groupsa

From: Spectrum of disease-causing mutations in protein secondary structures

Amino acid group Original residues Expected residues χ2 P value Mutant residues Expected residues χ2 P value
Hydrophobic 355 348 0.13 7.19E-01 320 322 0.01 9.13E-01
Positively charged 95 140 14.36*** 1.51E-04 85 71 2.75 9.71E-02
Negatively charged 196 147 16.56*** 4.71E-05 166 152 1.39 2.39E-01
Conformational 77 54 9.96** 1.60E-03 136 111 5.50* 1.90E-02
Polar 86 118 8.70** 3.17E-03 137 159 2.94 8.62E-02
A+T 119 121 0.04 8.34E-01 84 114 7.73** 5.44E-03
Sum 928 928    928 928   
  1. aχ2-numbers in italics indicate underrepresentation and numbers in bold overrepresentation compared to random distribution based on amino acid frequencies. The results of the χ2 are shown with significance level: * P < 0.05; ** P < 0.01; *** P < 0.001.