Spectrum of disease-causing mutations in protein secondary structures

BMC Structural Biology

Table 9 Spectrum of mutations in α-helices in amino acid groups^a

Amino acid group	Original residues	Expected residues	χ²	P value	Mutant residues	Expected residues	χ²	P value
Hydrophobic	355	348	0.13	7.19E-01	320	322	0.01	9.13E-01
Positively charged	95	140	14.36***	1.51E-04	85	71	2.75	9.71E-02
Negatively charged	196	147	16.56***	4.71E-05	166	152	1.39	2.39E-01
Conformational	77	54	9.96**	1.60E-03	136	111	5.50*	1.90E-02
Polar	86	118	8.70**	3.17E-03	137	159	2.94	8.62E-02
A+T	119	121	0.04	8.34E-01	84	114	7.73**	5.44E-03
Sum	928	928			928	928

^aχ²-numbers in italics indicate underrepresentation and numbers in bold overrepresentation compared to random distribution based on amino acid frequencies. The results of the χ² are shown with significance level: * P < 0.05; ** P < 0.01; *** P < 0.001.

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