Skip to main content

Table 2 Peptides used for binding to Brd2 BD2

From: Solution structure of the second bromodomain of Brd2 and its specific interaction with acetylated histone tails

Name

Sequence

Derivation

H2B-AcK5

SDPA-AcK-SAPAPKK

residues 1–12 of histone H2B

H4-AcK8

SGRGKGG-AcK-GLGK

residues 1–12 of histone H4

H4-AcK12

GKGLG-AcK-GGAKR

residues 7–17 of histone H4

H4-L10A

GKGAG-AcK-GGAKR

Leu 10 to Ala mutation of H4-AcK12

H4-L10G

GKGGG-AcK-GGAKR

Leu 10 to Gly mutation of H4-AcK12

H4-A15G

GKGLG-AcK-GGGKR

Ala 15 to Gly mutation of H4-AcK12

H4-acid

GDGLG-AcK-GGADE

Lys 8 to Asp, Lys 16 to Asp and Arg 17 to Glu mutations of H4-AcK12

H4-U

GKGLGKGGAKR

residues 7–17 of histone H4