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Figure 2 | BMC Structural Biology

Figure 2

From: The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor

Figure 2

Inhibition of hTAS1R2/hTAS1R3 by lactisole. (A-D) Concentration responses of cells transfected with hTAS1R2-hTAS1R3 DNAs to sweetners mixed with different lactisole concentrations. No lactisole present (filled circles, solid line), 50 μM lactisole (filled triangles up, dashed line), and 100 μM lactisole (filled squares, dash-dotted line). (E) EC50 values for acesulfame K, aspartame, NHDC, and cyclamate in the absence or presence of 50 μM and 100 μM lactisole.

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