Figure 1From: The structure of Mycobacteria 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, an essential enzyme, provides a platform for drug discoveryThe IspF reaction. IspF catalyzes the formation of 2C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) and CMP by an internal direct attack of the 2-phosphate group on the β-phosphate of the substrate, 4-diphosphocytidyl-2C-methyl-D-erythritol-2-phosphate (CDP-ME2P). The reaction is dependent on divalent cations (Zn2+ and under physiological conditions Mg2+).Back to article page