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Figure 4 | BMC Structural Biology

Figure 4

From: The structure of Mycobacteria 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, an essential enzyme, provides a platform for drug discovery

Figure 4

IspF homology. Amino acid sequence alignment of Ms IspF, Mt IspF, and Ec IspF. Secondary structure elements of Ms IspF are shown above the sequence. β-strands are blue, α-helices red, and 310-helical segments aquamarine. Ms IspF and Ec IspF are aligned based on a structural overlay. Residues boxed in black are strictly conserved and those in grey are identical in two of the three sequences; similar residues from the Mycobacteria sequences are outlined in a purple box. ▲ identifies residues that interact with Zn2+, τ with Mg2+, H with CDP, and ♥ with the 2C-methyl-D-erythritol moiety of substrate; λ denotes residues that line the hydrophobic cavity. The residues that bind Mg2+ and the ME2P fragment of substrate are based on observations in Ec IspF.

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