Figure 7

The α-helix N and the nascent base pair conformations in the wild-type and mutant 8-oxoG:dATP complexes. The final conformations of α-helices N and the nascent base pair in the wild-type (magenta) and Y271A mutant (yellow) pol β complex simulations with 8-oxoG:dA TP are superimposed according to their palm subdmains and compared to the crystal open (green) and closed (red) structures.