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Figure 3 | BMC Structural Biology

Figure 3

From: Fragment-based identification of determinants of conformational and spectroscopic change at the ricin active site

Figure 3

Ligand effects on active site conformation. (A) RTA without bound ligand (1IFT [7]). Figure made in stereo with SPDBV [46] and POV-Ray. (B) RTA with bound adenine. The position of Tyr80 in structure 1IFS is shown in cyan, and in 2P8N in yellow. (C) Closer view of the effect of binding adenine on the active site. Tyr80 in structure 1IFT (without adenine) is in green, 1IFS in cyan, and 2P8N in yellow. The 2mFo-DFc electron density of Tyr80 in 2P8N is contoured at 1.5σ. (D) RTA-NMU complex. A single water molecule is shown in light blue. (E) RTA-urea complex.

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BMC Structural Biology

ISSN: 1472-6807

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