Example of complex non-sequential alignment. Structures UDP-galactose 4-epimerase (PDB-code 1kvu, shown on a) andcatechol o-methylstransferase (PDB-code 1vid, shown on b) have been aligned by TOPOFIT with N
/RMSD 137/1.7 Å. Five alignment segments are shown by different colors; four of them are non-sequential. c) displays an alignment plot corresponding to the alignment. d) displays a schematic linear diagram of segment permutation in the alignment.