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Table 3 Distribution of non-sequential (NS) alignments among different protein folds as defined by SCOP.

From: A comprehensive analysis of non-sequential alignments between all protein structures

Fold % of all NS alignments (dataset D1) % of all alignments in fold (dataset D1) % of all NS alignments (dataset D2) % of all alignments in fold (dataset D2)
c.1) TIM α/β-barrel 35.1 32.5 25.8 33.6
b.69) 7-bladed β-propeller 2.8 66.3 5.3 71.4
c.66) S-ALMD methiltrtansferase 4.4 34.0 4.2 11.2
b.68) 6-bladed β-propeller 1.6 47.3 3.4 70.4
a.102) α/α a toroid 0.90 44.0 1.8 46.5
c.69) α/β-Hydrolase 0.99 6.3 1.4 4.2
b.82) Double-stranded β-helix 0.50 15.7 1.2 21.9
b.29) Concanavalin A-like lectins/glucanases 0.74 34.0 0.9 22.7
b.80) Right-handed β-helix 0.2 11.9 0.7 11.8
d.159) Metallo-dependent phosphatases 0.2 30.7 0.6 35.0
f.4) Transmembrane β-barrels 0.67 32.1 0.5 18.2
d.142) ATP-grasp 0.01 7.1 0.4 30.1
a.24) 4-helical up-and-down bundle 1.7 30.0 0.4 17.4
c.72) Ribokinase-like 0.6 40.1 0.4 40.0
h.4) Antiparallel coiled-coil 0.52 15.0 0.3 12.0
c.68) Nucleotide-diphospho-sugar transferases 0.07 5.7 0.3 14.3
b.67) 5-bladed β-propeller 0.2 48.4 0.3 50.0
c.2) NAD(P)-binding Rossmann-fold domains 6.8 32.8 0.3 21.4
c.3) FAD/NAD(P)-binding domain 4.4 22.2 0.3 42.9
Other folds 18.9 -- 2.5 --
Different folds or no fold assignment 18.7 41.8 48.9 31.9
  1. The line "Other folds" shows the percentage of non-sequential cases in all other folds not in the table. The last line shows the percentages of non-sequential alignments where compared proteins have different fold assignments or do not have an assigned fold.