Table 3 Distribution of non-sequential (NS) alignments among different protein folds as defined by SCOP.
From: A comprehensive analysis of non-sequential alignments between all protein structures
Fold | % of all NS alignments (dataset D1) | % of all alignments in fold (dataset D1) | % of all NS alignments (dataset D2) | % of all alignments in fold (dataset D2) |
|---|---|---|---|---|
c.1) TIM α/β-barrel | 35.1 | 32.5 | 25.8 | 33.6 |
b.69) 7-bladed β-propeller | 2.8 | 66.3 | 5.3 | 71.4 |
c.66) S-ALMD methiltrtansferase | 4.4 | 34.0 | 4.2 | 11.2 |
b.68) 6-bladed β-propeller | 1.6 | 47.3 | 3.4 | 70.4 |
a.102) α/α a toroid | 0.90 | 44.0 | 1.8 | 46.5 |
c.69) α/β-Hydrolase | 0.99 | 6.3 | 1.4 | 4.2 |
b.82) Double-stranded β-helix | 0.50 | 15.7 | 1.2 | 21.9 |
b.29) Concanavalin A-like lectins/glucanases | 0.74 | 34.0 | 0.9 | 22.7 |
b.80) Right-handed β-helix | 0.2 | 11.9 | 0.7 | 11.8 |
d.159) Metallo-dependent phosphatases | 0.2 | 30.7 | 0.6 | 35.0 |
f.4) Transmembrane β-barrels | 0.67 | 32.1 | 0.5 | 18.2 |
d.142) ATP-grasp | 0.01 | 7.1 | 0.4 | 30.1 |
a.24) 4-helical up-and-down bundle | 1.7 | 30.0 | 0.4 | 17.4 |
c.72) Ribokinase-like | 0.6 | 40.1 | 0.4 | 40.0 |
h.4) Antiparallel coiled-coil | 0.52 | 15.0 | 0.3 | 12.0 |
c.68) Nucleotide-diphospho-sugar transferases | 0.07 | 5.7 | 0.3 | 14.3 |
b.67) 5-bladed β-propeller | 0.2 | 48.4 | 0.3 | 50.0 |
c.2) NAD(P)-binding Rossmann-fold domains | 6.8 | 32.8 | 0.3 | 21.4 |
c.3) FAD/NAD(P)-binding domain | 4.4 | 22.2 | 0.3 | 42.9 |
Other folds | 18.9 | -- | 2.5 | -- |
Different folds or no fold assignment | 18.7 | 41.8 | 48.9 | 31.9 |