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Figure 6 | BMC Structural Biology

Figure 6

From: Neutral evolution of Protein-protein interactions: a computational study using simple models

Figure 6

The population dynamics enhance robustness and functionality. A) Φ(n) = ⟨n⟩ ss /⟨n⟩random measures the enrichment in mutational robustness due to the steady state dynamics. Each colored point corresponds to a 2D protein pair subjected to a dimerization condition. Each color corresponds to a particular level of the selection stringency, indicated by the value of the concentration threshold δ (in %, legend on right). Data are shown for a selection of 15 dimers. B) Φ([AB]) = ⟨[AB]⟩ ss /⟨[AB]⟩random measures the enrichment in dimerization ability due to the steady state dynamics: ⟨[AB]⟩ ss is the cellular concentration of the functional dimer averaged over the steady state sequences; ⟨[AB]⟩random is the value averaged over the viable sequences, regardless of their population. A value of Φ([AB]) greater than 1 indicates an enrichment of the steady state population in sequences that readily dimerize. Colors indicate the selection stringency. Data are shown for a selection of 10 dimers.

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