Error-scaled difference distance matrices generated by pair-wise comparisons of the eight complex structures. A. Error-scaled difference distance matrices from pair-wise comparisons of all eight structures using ESCET program. The pdb codes and the bound inhibitors in the eight structures are: 1XNZ, 1; 2EVM, 2, 2EVC, 3; 2Q92, 4; 2Q93, 5; 2Q94, 6; 2Q95, 7; and 2Q96, 8. All changes in distances smaller than the threshold 1σ are shown in grey; differences between this lower limit and an upper limit of 8σ are shown using a colour gradient where red stands for expansion and blue for contraction, light colours represent small changes and dark colours large changes; all differences larger than the upper limit are shown as full blue and full red, respectively. The gradients used for colour coding are also shown separately at the bottom of the figure. B. Enlarged one of the matrices in A, showing the comparison between 1XNZ and 2Q96. For clarity, the matrices underwent 2 × 2 binning (maintaining the element with the highest absolute value in the respective binning area) before being displayed.