Structural comparison between E. coli MetAP and human MetAPs. Structure of E. coli MetAP used in the overlays is the one complexed with 4 and coloured grey. (A) Overlay with human type I MetAP (PDB code 2NQ7) that is coloured cyan for the catalytic domain and blue for the N-terminal extension. (B) Overlay with human type II MetAP (PDB code 1B59) that is coloured magenta for the catalytic domain, orange for the N-terminal extension and red for the insert. (C) Schematic drawing of the domains in E. coli MetAP and human MetAPs.