Figure 3

Schematic ribbon representation of the structures of 1DF3 (A, B) and LIR2 (C, D). Residues implicated in the external (B, D) and internal (A, C) clusters are shown in ball and stick. Hydrophobic residues are represented in orange. For LIR2 the disulfide bonds are in yellow and the hydrophilic residues in blue. The hydrophobic belt includes positions (in brackets : corresponding residue for LIR2) 48 (Trp), 80 (Val), 91 (Phe), 93 (Tyr), 115 (Leu), 131 (Met), 133 (Phe), 156 (Asn), 158 (Val), 168 (Thr), 170 (Leu), 190 (Trp), 192 (Ala) and the external cluster 52 (Arg), 159 (Leu), 169 (Ile), 171 (Arg), 189 (Leu), 205(Cys), 220 (Phe; not interacting with the cluster).