Table 1 Hyperthermophilic/Mesophilic (1–24) and Thermophilic/Mesophilic (25–38) pairs in dataset A*
ID | PDB | Class | Organism | Res (Å) | PDB | Class | Mesophile | Res (Å) | ΔÅ | %identity | Functional Class | Description |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 1A2Z A | a/b | Thermococcus litoralis | 1.73 | 1AUG A | a/b | Bacillus amyloliquefaciens | 2.00 | 0.27 | 37 | Peptidase | Pyrrolidone Carboxyl Peptidase |
2 | 1A53 0 | a/b | Sulfolobus solfataricus | 2.00 | 1PII 0 | a/b | Escherichia coli | 2.00 | 0.00 | 38 | Synthase | Indole-3-Glycerolphosphate Synthase |
3 | 1DD3 A | a/b | Thermotoga maritima | 2.00 | 1CTF 0 | a/b | Escherichia coli | 1.70 | 0.3 | 69 | Ribosomal | Ribosomal Protein |
4 | 1DQI A | mainly b | Pyrococcus furiosus | 1.70 | 1DFX 0 | mainly b | D. desulfuricans | 1.90 | 0.20 | 34 | Oxidoreductase | Superoxide Reductase |
5 | 1FTR A | a+b | Methanopyrus kandleri | 1.70 | 1M5S A | a+b | Methanosarcina barkeri | 1.85 | 0.15 | 59 | Transferase | Formyltransferase |
6 | 1G29 1 | a/b | Thermococcus litoralis | 1.90 | 1B0U A | a/b | Salmonella typhimurium | 1.50 | 0.40 | 31 | Sugar Binding | Malk Protein |
7 | 1HQK A | a/b | Aquifex aeolicus | 1.60 | 1W19 A | a/b | M. tuberculosis | 2.00 | 0.40 | 50 | Transferase | Lumazine Synthase |
8 | 1IU8 A | a/b | Pyrococcus horikoshii | 1.60 | 1AUG A | a/b | Bacillus amyloliquefaciens | 2.00 | 0.40 | 45 | Hydrolase | Pyrrolidone-Carboxylate Peptidase |
9 | 1J31 A | a/b | Pyrococcus horikoshii | 1.60 | 1UF5 A | a/b | Agrobacterium sp. | 1.60 | 0.00 | 31 | Unknown | Hypothetical Protein Ph0642 |
10 | 1JI0 A | a/b | Thermotoga maritima | 2.00 | 1G6H A | a/b | Escherichia coli | 1.60 | 0.40 | 31 | Carrier | Abc Transporter |
11 | 1JVB A | a/b | Sulfolobus solfataricus | 1.85 | 1M6H A | a/b | Homo sapiens | 2.00 | 0.15 | 31 | Oxidoreductase | Alcohol Dehydrogenase |
12 | 1LK5 A | a/b | Pyrococcus horikoshii | 1.75 | 1M0S A | a/b | Haemophilus influenzae | 1.90 | 0.15 | 42 | Isomerase | D-Ribose-5-Phosphate Isomerase |
13 | 1M2K A | a/b | Archaeoglobus fulgidus | 1.47 | 1S5P A | a/b | Escherichia coli | 1.96 | 0.49 | 41 | Trascriptional Regulator | Sir2 Homologue |
14 | 1M5H A | a+b | Archaeoglobus fulgidus | 2.00 | 1M5S A | a+b | Methanosarcina barkeri | 1.85 | 0.15 | 68 | Transferase | Formyltransferase |
15 | 1NSJ 0 | a/b | Thermotoga maritima | 2.00 | 1PII 0 | a/b | Escherichia coli | 2.00 | 0.00 | 33 | Isomerase | P-Ribosylanthranilate Isomerase |
16 | 1P1L A | a/b | Archaeoglobus fulgidus | 2.00 | 1NAQ A | a/b | Escherichia coli | 1.70 | 0.3 | 33 | Unknown | Cation Resistent Protein Cut-A |
17 | 1U1I A | a/b | Archaeoglobus fulgidus | 1.90 | 1P1J A | a/b | Saccharomyces cerevisiae | 1.70 | 0.20 | 31 | Isomerase | Myo-Inositol Phosphate Synthase |
18 | 1UKU A | a/b | Pyrococcus horikoshii | 1.45 | 1NAQ A | a/b | Escherichia coli | 1.70 | 0.25 | 39 | Metal Binding Protein | Cation Resistent Protein Cut-A |
19 | 1V3W A | mainly b | Pyrococcus horikoshii | 1.50 | 1XHD A | mainly b | Bacillus cereus | 1.90 | 0.40 | 40 | Lyase | Ferripyochelin Binding Protein |
20 | 1V7R A | a/b | Pyrococcus horikoshii | 1.40 | 1K7K A | a/b | Escherichia coli | 1.50 | 0.10 | 34 | Hydrolase | Hypothetical Protein Ph1917 |
21 | 1VE0 A | a/b | Sulfolobus tokodaii | 2.00 | 1VMH A | a/b | C. acetobutylicum | 1.31 | 0.69 | 42 | Metal Binding Protein | Hypothetical Protein St2072 |
22 | 1VPE 0 | a/b | Thermotoga maritima | 2.00 | 1HDI A | a/b | Sus scrofa | 1.80 | 0.20 | 47 | Transferase | Phosphoglycerate Kinase |
23 | 1XGS A | mainly a | Pyrococcus furiosus | 1.75 | 1B6A 0 | mainly a | Homo sapiens | 1.60 | 0.15 | 40 | Aminopeptidase | Methionine Aminopeptidase |
24 | 1XTY A | a/b | Pyrococcus abyssi | 1.80 | 1Q7S A | a/b | Homo sapiens | 2.00 | 0.20 | 48 | Hydrolase | Peptidyl-Trna Hydrolase |
25 | 1EE8 A | mainly a | Thermus thermophilus | 1.90 | 1TDZ A | mainly a | Lactococcus lactis | 1.80 | 0.10 | 35 | Dna Binding Protein | Fpg Protein |
26 | 1GD7 A | mainly b | Thermus thermophilus | 2.00 | 1PXF A | mainly b | Escherichia coli | 1.87 | 0.13 | 34 | Rna Binding Protein | Csaa Protein |
27 | 1J09 A | a/b | Thermus thermophilus | 1.80 | 1NZJ A | a/b | Escherichia coli | 1.50 | 0.30 | 33 | Ligase | Glutamil-Trna Synthase |
28 | 1J3N A | a/b | Thermus thermophilus | 2.00 | 1E5M A | a/b | Synechocystis sp. | 1.54 | 0.46 | 55 | Transferase | Acyl Carrier Protein |
29 | 1JBO A | mainly a | T. elongatus | 1.45 | 1B8D A | mainly a | Griffithsia monilis | 1.90 | 0.45 | 38 | Photosynthesis | Phycocyanin |
30 | 1MNG A | mainly a | Thermus thermophilus | 1.80 | 1GV3 A | mainly a | Anabaena sp. | 2.00 | 0.20 | 59 | Oxidoreductase | Superoxide Dismutase |
31 | 1SRV A | a/b | Thermus thermophilus | 1.70 | 1KID 0 | a/b | Escherichia coli | 1.70 | 0.00 | 69 | Chaperone | Groel |
32 | 1UZB A | a/b | Thermus thermophilus | 1.40 | 1O0A A | a/b | Halobacterium salinarum | 1.42 | 0.02 | 34 | Oxidoreductase | 1-Pyrroline-5-Carboxylate Dehydrogenase |
33 | 1V6S A | a/b | Thermus thermophilus | 1.50 | 16PK 0 | a/b | Trypanosoma brucei | 1.60 | 0.10 | 43 | Transferase | Phosphoglycerate Kinase |
34 | 1V8F A | a/b | Thermus thermophilus | 1.90 | 1N2E A | a/b | M. tuberculosis | 1.60 | 0.30 | 55 | Ligase | Pantothenate Synthetase |
35 | 1VC4 A | a/b | Thermus thermophilus | 1.80 | 1PII 0 | a/b | Escherichia coli | 2.00 | 0.20 | 37 | Lyase | Indole-3-Glycerolphosphate Synthase |
36 | 1VCD A | a/b | Thermus thermophilus | 1.70 | 1SJY A | a/b | Deinococcus radiodurans | 1.39 | 0.31 | 34 | Hydrolase | Ap6a Hydroxylase Ndx1 |
37 | 1YYA A | a/b | Thermus thermophilus | 1.60 | 1MO0 A | a/b | Caenorhabditis elegans | 1.70 | 0.10 | 44 | Isomerase | Triosephosphate Isomerase |
38 | 2PRD 0 | a/b | Thermus thermophilus | 2.00 | 1SXV A | a/b | M. tuberculosis | 1.30 | 0.70 | 51 | Hydrolase | Inorganic Pyrophosphatase |