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Table 5 Preferred amino acid interactions in CHCs. Hyperthermophilic versus mesophilic proteins of dataset A are compared*

From: "Hot cores" in proteins: Comparative analysis of the apolar contact area in structures from hyper/thermophilic and mesophilic organisms

  ALA VAL PHE ILE LEU ASP GLU GLY LYS SER THR TYR CYS ASN GLN PRO MET ARG HIS TRP XXX
ALA -2.03                     
VAL -0.36 -0.55                    
PHE 0.85 -0.46 -0.26                   
ILE 3.07 6.09 3.17 4.33                  
LEU -4.00 -1.11 0.42 3.82 -4.56                 
ASP -1.23 0.05 -0.49 0.88 -0.23 -0.13                
GLU -0.83 0.46 0.49 0.04 2.71 -0.13 0.95               
GLY -0.60 -0.52 -0.35 0.81 -0.45 -0.51 0.92 0.01              
LYS -1.73 -1.03 0.46 2.45 1.13 -0.48 2.37 0.39 0.98             
SER -0.87 -0.35 -0.08 1.13 -0.60 -0.16 0.07 -0.81 0.48 0.11            
THR -1.48 -0.43 -0.40 0.02 -1.03 0.04 -1.01 0.52 0.29 0.13 0.16           
TYR -0.23 1.54 0.17 1.44 -1.51 0.37 -0.19 0.22 -0.49 0.38 -0.08 0.53          
CYS -1.76 -1.79 -0.67 -0.57 -3.03 -0.17 -0.01 -0.59 -0.35 -0.77 -0.37 -0.30 -0.12         
ASN 0.67 0.20 0.01 0.33 -0.82 -0.27 0.22 0.24 0.16 -0.23 -0.56 -0.59 0.06 0.06        
GLN -1.19 -0.88 0.12 0.23 -2.61 -0.34 -1.13 -0.55 0.31 -0.56 -1.32 -0.56 -0.16 -0.04 -0.23       
PRO 0.03 -0.73 0.36 0.27 0.10 0.15 0.71 0.75 0.49 -0.16 -0.32 -0.21 -0.48 0.44 -0.49 0.21      
MET -0.85 0.44 -0.08 1.22 -0.23 -0.29 0.79 -0.61 0.31 0.23 0.29 -0.25 -0.57 0.15 -0.23 -0.12 0.04     
ARG -0.31 1.08 0.15 1.65 1.01 -0.12 1.51 -0.04 0.10 -0.07 -0.05 0.49 0.05 -0.18 -0.60 0.34 0.43 0.49    
HIS -0.50 0.23 -0.13 0.28 -1.55 -0.24 -0.92 0.06 -0.93 -0.11 -0.24 0.16 -0.55 -0.05 -0.02 -0.02 -0.05 -0.14 0.37   
TRP 0.01 -0.40 -0.19 0.64 0.55 0.20 0.95 -0.11 -0.25 -0.08 -0.06 -0.30 -0.14 -0.48 -0.04 0.25 -0.23 0.46 -0.48 0.21  
XXX 0.35 0.09 0.39 0.61 0.74 0.22 0.35 0.04 0.09 0.23 0.26 0.23 0.00 0.05 0.09 0.18 0.00 0.06 -0.08 0.09 0.13
  1. * Values are expressed in units of standard deviation from the mean (Z-score). Values ≥ 3.0 are considered statistically significant and are bolded. Mean = 0.00; standard deviation = 0.10.