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Table 7 Preferred amino acid substitutions in CHCs. Hyperthermophilic versus mesophilic proteins of dataset A are compared*

From: "Hot cores" in proteins: Comparative analysis of the apolar contact area in structures from hyper/thermophilic and mesophilic organisms

  TO HYPERTHERMOPHILE
   ALA VAL PHE ILE LEU ASP GLU GLY LYS SER THR TYR CYS ASN GLN PRO MET ARG HIS TRP XXX
FROM MESOPHILE ALA 0.00 3.20 1.28 1.67 -0.85 0.26 1.79 0.47 1.92 -0.13 -2.22 0.04 -2.48 -0.38 0.43 -0.30 -1.02 -0.13 -0.64 0.09 0.00
  VAL -3.20 0.00 1.07 6.31 -1.58 -0.30 0.21 -0.60 0.13 0.21 -1.79 0.38 -2.09 -0.73 -0.13 0.34 0.34 0.90 0.04 -0.26 0.00
  PHE -1.28 -1.07 0.00 2.31 -0.73 -0.26 0.04 -0.09 0.38 -0.21 0.60 0.51 -0.21 -0.38 -0.30 0.13 1.54 -0.47 -0.21 -0.64 0.00
  ILE -1.67 -6.31 -2.31 0.00 -6.36 0.47 0.51 -0.60 0.60 -0.21 0.30 -0.09 -0.34 -0.77 -0.90 0.00 0.90 -1.11 -1.02 -0.09 -0.17
  LEU 0.85 1.58 0.73 6.36 0.00 0.13 -0.90 0.30 -1.02 -0.30 0.21 -0.13 -1.71 0.26 -0.90 0.13 -1.62 1.37 -0.68 0.38 0.00
  ASP -0.26 0.30 0.26 -0.47 -0.13 0.00 1.32 0.09 0.73 -0.13 -0.21 0.09 0.00 -0.77 0.09 -0.13 0.00 0.13 0.51 0.04 0.00
  GLU -1.79 -0.21 -0.04 -0.51 0.90 -1.32 0.00 -0.30 -0.94 -0.73 -0.47 0.04 -0.47 -0.43 -1.07 -0.47 -0.09 0.17 -0.17 -0.17 0.00
  GLY -0.47 0.60 0.09 0.60 -0.30 -0.09 0.30 0.00 -0.30 -1.28 0.38 0.38 0.00 0.51 -0.51 -0.09 0.00 0.77 0.17 0.00 0.00
  LYS -1.92 -0.13 -0.38 -0.60 1.02 -0.73 0.94 0.30 0.00 0.00 -1.02 -0.38 -0.30 -0.04 -1.11 -0.26 0.04 0.77 -0.60 0.13 0.00
  SER 0.13 -0.21 0.21 0.21 0.30 0.13 0.73 1.28 0.00 0.00 1.58 0.00 0.09 -0.56 -0.43 0.30 0.13 0.43 -0.09 -0.13 0.00
  THR 2.22 1.79 -0.60 -0.30 -0.21 0.21 0.47 -0.38 1.02 -1.58 0.00 -0.21 -0.51 0.04 0.26 0.34 -0.30 0.34 0.56 -0.47 0.00
  TYR -0.04 -0.38 -0.51 0.09 0.13 -0.09 -0.04 -0.38 0.38 0.00 0.21 0.00 -0.81 -0.26 -0.13 0.17 0.43 -0.85 0.34 0.43 0.00
  CYS 2.48 2.09 0.21 0.34 1.71 0.00 0.47 0.00 0.30 -0.09 0.51 0.81 0.00 0.13 0.04 0.17 0.90 0.13 0.26 0.00 0.00
  ASN 0.38 0.73 0.38 0.77 -0.26 0.77 0.43 -0.51 0.04 0.56 -0.04 0.26 -0.13 0.00 -0.85 -0.04 -0.26 -0.13 -0.13 0.13 0.00
  GLN -0.43 0.13 0.30 0.90 0.90 -0.09 1.07 0.51 1.11 0.43 -0.26 0.13 -0.04 0.85 0.00 0.56 -0.38 0.38 0.13 0.43 0.00
  PRO 0.30 -0.34 -0.13 0.00 -0.13 0.13 0.47 0.09 0.26 -0.30 -0.34 -0.17 -0.17 0.04 -0.56 0.00 -0.17 0.17 -0.21 0.09 0.00
  MET 1.02 -0.34 -1.54 -0.90 1.62 0.00 0.09 0.00 -0.04 -0.13 0.30 -0.43 -0.90 0.26 0.38 0.17 0.00 -0.64 -0.47 0.38 -0.30
  ARG 0.13 -0.90 0.47 1.11 -1.37 -0.13 -0.17 -0.77 -0.77 -0.43 -0.34 0.85 -0.13 0.13 -0.38 -0.17 0.64 0.00 -0.98 0.43 0.00
  HIS 0.64 -0.04 0.21 1.02 0.68 -0.51 0.17 -0.17 0.60 0.09 -0.56 -0.34 -0.26 0.13 -0.13 0.21 0.47 0.98 0.00 0.00 0.00
  TRP -0.09 0.26 0.64 0.09 -0.38 -0.04 0.17 0.00 -0.13 0.13 0.47 -0.43 0.00 -0.13 -0.43 -0.09 -0.38 -0.43 0.00 0.00 0.00
  XXX 0.00 0.00 0.00 0.17 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.30 0.00 0.00 0.00 0.00
  1. * Values are expressed in units of standard deviation from the mean (Z-score). Values ≥ 3.0 are considered statistically significant and are bolded. Mean = 0.00; standard deviation = 23.41.