Table 7 Preferred amino acid substitutions in CHCs. Hyperthermophilic versus mesophilic proteins of dataset A are compared*
| Â | TO HYPERTHERMOPHILE | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | Â | ALA | VAL | PHE | ILE | LEU | ASP | GLU | GLY | LYS | SER | THR | TYR | CYS | ASN | GLN | PRO | MET | ARG | HIS | TRP | XXX |
FROM MESOPHILE | ALA | 0.00 | 3.20 | 1.28 | 1.67 | -0.85 | 0.26 | 1.79 | 0.47 | 1.92 | -0.13 | -2.22 | 0.04 | -2.48 | -0.38 | 0.43 | -0.30 | -1.02 | -0.13 | -0.64 | 0.09 | 0.00 |
| Â | VAL | -3.20 | 0.00 | 1.07 | 6.31 | -1.58 | -0.30 | 0.21 | -0.60 | 0.13 | 0.21 | -1.79 | 0.38 | -2.09 | -0.73 | -0.13 | 0.34 | 0.34 | 0.90 | 0.04 | -0.26 | 0.00 |
| Â | PHE | -1.28 | -1.07 | 0.00 | 2.31 | -0.73 | -0.26 | 0.04 | -0.09 | 0.38 | -0.21 | 0.60 | 0.51 | -0.21 | -0.38 | -0.30 | 0.13 | 1.54 | -0.47 | -0.21 | -0.64 | 0.00 |
| Â | ILE | -1.67 | -6.31 | -2.31 | 0.00 | -6.36 | 0.47 | 0.51 | -0.60 | 0.60 | -0.21 | 0.30 | -0.09 | -0.34 | -0.77 | -0.90 | 0.00 | 0.90 | -1.11 | -1.02 | -0.09 | -0.17 |
| Â | LEU | 0.85 | 1.58 | 0.73 | 6.36 | 0.00 | 0.13 | -0.90 | 0.30 | -1.02 | -0.30 | 0.21 | -0.13 | -1.71 | 0.26 | -0.90 | 0.13 | -1.62 | 1.37 | -0.68 | 0.38 | 0.00 |
| Â | ASP | -0.26 | 0.30 | 0.26 | -0.47 | -0.13 | 0.00 | 1.32 | 0.09 | 0.73 | -0.13 | -0.21 | 0.09 | 0.00 | -0.77 | 0.09 | -0.13 | 0.00 | 0.13 | 0.51 | 0.04 | 0.00 |
| Â | GLU | -1.79 | -0.21 | -0.04 | -0.51 | 0.90 | -1.32 | 0.00 | -0.30 | -0.94 | -0.73 | -0.47 | 0.04 | -0.47 | -0.43 | -1.07 | -0.47 | -0.09 | 0.17 | -0.17 | -0.17 | 0.00 |
| Â | GLY | -0.47 | 0.60 | 0.09 | 0.60 | -0.30 | -0.09 | 0.30 | 0.00 | -0.30 | -1.28 | 0.38 | 0.38 | 0.00 | 0.51 | -0.51 | -0.09 | 0.00 | 0.77 | 0.17 | 0.00 | 0.00 |
| Â | LYS | -1.92 | -0.13 | -0.38 | -0.60 | 1.02 | -0.73 | 0.94 | 0.30 | 0.00 | 0.00 | -1.02 | -0.38 | -0.30 | -0.04 | -1.11 | -0.26 | 0.04 | 0.77 | -0.60 | 0.13 | 0.00 |
| Â | SER | 0.13 | -0.21 | 0.21 | 0.21 | 0.30 | 0.13 | 0.73 | 1.28 | 0.00 | 0.00 | 1.58 | 0.00 | 0.09 | -0.56 | -0.43 | 0.30 | 0.13 | 0.43 | -0.09 | -0.13 | 0.00 |
| Â | THR | 2.22 | 1.79 | -0.60 | -0.30 | -0.21 | 0.21 | 0.47 | -0.38 | 1.02 | -1.58 | 0.00 | -0.21 | -0.51 | 0.04 | 0.26 | 0.34 | -0.30 | 0.34 | 0.56 | -0.47 | 0.00 |
| Â | TYR | -0.04 | -0.38 | -0.51 | 0.09 | 0.13 | -0.09 | -0.04 | -0.38 | 0.38 | 0.00 | 0.21 | 0.00 | -0.81 | -0.26 | -0.13 | 0.17 | 0.43 | -0.85 | 0.34 | 0.43 | 0.00 |
| Â | CYS | 2.48 | 2.09 | 0.21 | 0.34 | 1.71 | 0.00 | 0.47 | 0.00 | 0.30 | -0.09 | 0.51 | 0.81 | 0.00 | 0.13 | 0.04 | 0.17 | 0.90 | 0.13 | 0.26 | 0.00 | 0.00 |
| Â | ASN | 0.38 | 0.73 | 0.38 | 0.77 | -0.26 | 0.77 | 0.43 | -0.51 | 0.04 | 0.56 | -0.04 | 0.26 | -0.13 | 0.00 | -0.85 | -0.04 | -0.26 | -0.13 | -0.13 | 0.13 | 0.00 |
| Â | GLN | -0.43 | 0.13 | 0.30 | 0.90 | 0.90 | -0.09 | 1.07 | 0.51 | 1.11 | 0.43 | -0.26 | 0.13 | -0.04 | 0.85 | 0.00 | 0.56 | -0.38 | 0.38 | 0.13 | 0.43 | 0.00 |
| Â | PRO | 0.30 | -0.34 | -0.13 | 0.00 | -0.13 | 0.13 | 0.47 | 0.09 | 0.26 | -0.30 | -0.34 | -0.17 | -0.17 | 0.04 | -0.56 | 0.00 | -0.17 | 0.17 | -0.21 | 0.09 | 0.00 |
| Â | MET | 1.02 | -0.34 | -1.54 | -0.90 | 1.62 | 0.00 | 0.09 | 0.00 | -0.04 | -0.13 | 0.30 | -0.43 | -0.90 | 0.26 | 0.38 | 0.17 | 0.00 | -0.64 | -0.47 | 0.38 | -0.30 |
| Â | ARG | 0.13 | -0.90 | 0.47 | 1.11 | -1.37 | -0.13 | -0.17 | -0.77 | -0.77 | -0.43 | -0.34 | 0.85 | -0.13 | 0.13 | -0.38 | -0.17 | 0.64 | 0.00 | -0.98 | 0.43 | 0.00 |
| Â | HIS | 0.64 | -0.04 | 0.21 | 1.02 | 0.68 | -0.51 | 0.17 | -0.17 | 0.60 | 0.09 | -0.56 | -0.34 | -0.26 | 0.13 | -0.13 | 0.21 | 0.47 | 0.98 | 0.00 | 0.00 | 0.00 |
| Â | TRP | -0.09 | 0.26 | 0.64 | 0.09 | -0.38 | -0.04 | 0.17 | 0.00 | -0.13 | 0.13 | 0.47 | -0.43 | 0.00 | -0.13 | -0.43 | -0.09 | -0.38 | -0.43 | 0.00 | 0.00 | 0.00 |
| Â | XXX | 0.00 | 0.00 | 0.00 | 0.17 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.30 | 0.00 | 0.00 | 0.00 | 0.00 |