Multiple sequence alignment of FKBPs and FKBDs from different organisms. The standard colouring pattern of ClustalX  is used. Well and strictly conserved residues that are associated with binding of rapamycin in human FKBP12 and in Mip77–213 are labelled by black boxes. The functional equivalents F-153 in Mip77–213 and F-46 in human FKBP12 (black circles) are neither conserved nor aligned to the same sequence position. Graphical representation of the rate of conservation is indicated at the bottom. Proteins shown: Legionella pneumophila Mip, <Q5ZXE0>; Homo sapiens FKBP12, <P62942>; Bos Taurus FKBP1A, <P18203>; baker's yeasts FPR1, <P20081>; Corynebacterium glutamicum Cgl0830, <P42458>; Escherichia coli FKPA, <P45523>; Trypanosoma cruzi Mip, <Q09734>.