Figure 4

Cleft vs. backbone rmsd. The three boxplots correspond to the distributions of cleft rmsd relative to target-template seq.id. for models with (A) high (0 Å – 3 Å), (B) medium (3 Å – 6 Å) and (C) low (≥ 6 Å) backbone accuracy (computed as the rmsd of the C_α trace between experimental and modelled structures of the target). Please note the scale change between figures. In all three cases the dashed line represents the auto-model control (see Materials and Methods).