Figure 3

Distribution of local folding free energies over the residues of Gαi or Gαt. Free energies are given as ln(k_f) in the GDP or GTPγS bound forms of the proteins as indicated. Secondary structure elements are indicated as strips next to the x-axis (black for helices, grey for β-sheets) and named according to the convention given in figure 1. Known switch regions are also shown as grey strips numbered form I to IV on top of each picture. The two sequences are aligned and Swiss Prot residue numbering for Gαi is used in both cases.