Figure 5

Common folding correlations in GDP- or GTPγS-bound Gαi. Correlation matrix is calculated from top 5000 partially folded COREX states of Gαi-GDP and Gαi-GTPγS and is shown on a rainbow color scale (blue to red correspond to 0 to 1). The matrix is constructed as explained in the text and the sites are sorted from N to C terminal (left to right, top to bottom). Only the lower triangle of the symmetric matrix is shown. Yellow arrows indicate regions of very high local stability. An unambiguous correlation group is indicated with white arrows and mapped on the structure of Giα1 (inset). RasTop program v2.0.3 (Philippe Valadon, 2003) is used for 3D visualization.