Figure 1

Determination of crossover points. The Cα distances between different initial models (blue) are transformed into an envelope of these Cα distance variations (red) using the median filter formula [26]. The intersections of the envelope and the threshold (black) that is the mean of all these Cα distances is used as crossover points for mixing and matching between different initial models. Conserved stretches are those with a lower average Cα distance, and variable stretches are those with a higher average Cα distance [see the Method section on mixing and matching between two initial models].