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Table 2 S-P-A motif conservation in E2 enzymes

From: Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes

E2 enzyme

Loop 7 Sequence

Interacts w. CHIP?

Reference

Ubc1

DQWAAA

N

[20]

UbcH2

QTWTAL

N

[20]

Ubc3

ERWNP T

N

[18, 20]

UbcH7

ENWKPA

N

[18, 20]

UbcH8

ENWKP C

N

[18]

UbcH5a-c

SQWSPA

Y

[20]

Ubc13

DKWSPA

Y

[22, 24]

Ube2e1-3

DNWSPA

Y

*

  1. Residues on loop 7 of selected E2 enzymes, corresponding to the positions of the S-P-A motifs in UbcH5 and Ubc13.
  2. *Reported in this study.