Figure 4

Length adjustments in length-deviant superfamilies from the four major classes. Panels' I-IV depict 'dwarf and giant' representative members (left and right respectively) of a deviant superfamily from alpha, beta, alpha/beta and alpha +beta class. Representative members are indicated with PDB id and domain length. CUSP reported structurally conserved regions (SSB), whose lengths and structural type are retained across all domain superfamily members (in brown), are distinguished from unconserved regions/indels (USB, in green). (a) Cytochrome C superfamily 'giant' members are 56% more likely to adjust extra length as coils and short length helices.(b) Viral proteins from β-class have acquired additional strands and coils in indel regions. Up to two-fold length variations are seen as additional coils and helices in (c) Actin-like ATPase and (d) Lysozyme-like domain superfamilies.