Figure 3
From: The crystal structure of the putative peptide-binding fragment from the human Hsp40 protein Hdj1
Sequence alignment of the C-terminal regions from eukaryotic Type II Hsp40 family members. Program Pileup from GCG package was utilized to align residues 162–340 of Hdj1 from H. sapiens with similar regions of Hsp40 proteins from M. musculus (Hsp40-3), C. elegans (Z66513.1), D. Melanogaster (Droj-1), S. pombe (Psi protein) and S. cerevisiae (Sis1). The amino acid residue numbers of Hdj1 are numbered above the alignment. The residues involved in forming the peptide-binding site of Hdj1 are marked by blue bars. The secondary structures of Hdj1 are shown on top of the alignment. The structural components in domain I are denoted by blue and those in domain II are denoted by green. The α-helices are represented by boxes and β-strands are represented by arrows.