Figure 5
Effect of the relative Target:Template and Template1:Template2 sequence similarity on two-template model accuracy. (A) Definition of sequence similarities between Target, Template1, and Template2. (B) Difference in RMSD for models built using structure-based alignments (RMSDSTR.2.1 - RMSDSTR.2.2) as a function of Target:Template1 sequence identity (S1) for different ranges of [S1–S2]. The colored circles green, yellow, blue to red are in increasing order of [S1–S2]. The absence of data at lower sequence identity (for yellow, blue and red) is due to the fact that for large values [S1 – S2], small S1 is not possible. (C) Difference in RMSD for models built using structure-based alignments (RMSDSTR.2.1 - RMSDSTR.2.2) as a function of Target:Template1 sequence identity (S1) for different ranges of S3. The colored circles, green, blue to red, are in the increasing order of S3. Only models with S1 similar to S2 are shown here. The absence of data points (green and blue) for higher sequence identity is due to the fact that certain combinations of S1, S2, and S3 are not possible.