Figure 4

Stereo view of the superposed ligand binding sites from different species. The superposition was obtained using as reference structure (in yellow) the C. albicans TPK co-crystallised with TPNP (PDB id 2G9Z) and A) S. cerevisiae (Blue) (PDB id 1IG0), B) Mouse (green) (PDB id 2F17) C) C. albicans TPK co-crystallised with thiamine (red) (PDB id 2HH9). Residue numbers correspond to C. albicans numbering.