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Figure 6 | BMC Structural Biology

Figure 6

From: Docking of molecules identified in bioactive medicinal plants extracts into the p50 NF-kappaB transcription factor: correlation with inhibition of NF-kappaB/DNA interactions and inhibitory effects on IL-8 gene expression

Figure 6

Poses of docked compound 21 in to the DNA binding region of NF-kappaB p50. A. monomer and B. homodimer (chain A, shown in grey). The inhibitory activity of 21 may be due to its ability to form a stable complex with the active conformation of the dimer and/or blocking the interaction of DNA with the monomer filling the protein binding site. The DNA was obtained from the crystal structure of the homodimer NF-kappaB (pdb code:1NFK). The surface of the protein is represented in wire frame, the ligand and DNA are highlighted in VDW and stick representation respectively.

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BMC Structural Biology

ISSN: 1472-6807

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