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Figure 3 | BMC Structural Biology

Figure 3

From: Multiple molecular dynamics simulation of the isoforms of human translation elongation factor 1A reveals reversible fluctuations between "open" and "closed" conformations and suggests specific for eEF1A1 affinity for Ca2+-calmodulin

Figure 3

Distance between centers of domains I and II (a-d) and minimal distance between regions Arg69-Leu77 and His295-Gly305 (e, f). a, e – eEF1A1: red – trajectory 1, green – trajectory 2, blue – trajectory 3, cyan – trajectory 4, magenta – trajectory 5, yellow – trajectory 6. b, f – eEF1A2: red – trajectory 7, green – trajectory 8, blue – trajectory 9, cyan – trajectory 10, magenta – trajectory 11, yellow – trajectory 12, orange – trajectory 13. c – the mean distances between centers of the domains I and II for eEF1A1 (black) and eEF1A2 (red); averaging has been done for all respective trajectories. d – the mean distances between the centers of domains I and II after the exemption of the trajectories characterized by the existence of "closed" conformation for more than 500 ps (1, 6 for eEF1A1 and 7, 8, 13 for eEF1A2).

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