Table 4 Prediction rules between classes in SCOP and PROSITE obtained by cross-training

All α Proteins.Globin like → Globinsfamily profile 0.323

All α Proteins.Globin like → Legume lectins signatures 0.079

All β Proteins.Cupredoxin like → Type-1 copper blue proteins signature 0.200

All β proteins.Galactose-binding domain-like →C-type lectin domain signature & profile 0.182

All β Proteins.Nucleoplasmin-like VP viral coat & capsid→ DEAD & DEAH box families ATP-dependent helicases signatures 0.14

α &β proteins.NADP- binding Rossmann-fold domains → C-type lectin domain signature & profile 0.103

All β proteins.Double-stranded β-helix → EF-hand calcium-binding domain 0.086

All α Proteins.EF Hand like → EF-hand calcium-binding domain 0.090

All β Proteins.Immunoglobulin-like β sandwich → Immunoglobulins & MHC proteins 0.034

All β Proteins.Immunoglobulin-like β sandwich → Ig-like domain profile 0.064

α &β Proteins.α β-Hydrolases → EF-hand calcium-binding domain 0.086

α &β proteins.Ferredoxin-like → 4Fe-4S ferredoxins iron sulfur binding region signature 0.024

α &β proteins. P-loop containing nucleoside triphosphatehydrolases → Heavy-metal-associated domain signature & profile 0.037

α &β proteins.Thioredoxin fold → Pyridine nucleotide-disulphide oxidoreductases class-I active site 0.097

All α proteins.Four-helical up-&-down bundle → Cytochrome c family heme-binding site signature 0.094

Membrane & cell surface proteins and peptides → C-type lectin domain signature & profile 0.092

All β proteins.Concanavalin A-like lectins glucanases → C-type lectin domain signature & profile 0.084

All α proteins.DNA RNA-binding 3-helical bundle → TNFR NGFR family cysteine-rich region signature & profile 0.062

Small proteins → Serine proteases trypsin family signatures & profile 0.010

Small proteins → Ig-like domain profile 0.047

Rules: Functional-properties (PROSITE class) ⇒ Structural-properties (SCOP class)

Globins family profile → All α proteins.Globin-like 0.369

Serine proteases trypsin family signatures & profile → Small proteins 0.722

Protein kinases signatures & profile → Small proteins 0.662

Legume lectins signatures → All α proteins.Globin-like 0.060

Cytochrome c family heme-binding site signature → All β proteins.Barrel-sandwich hybrid 0.029