Figure 1From: Protein Functional Surfaces: Global Shape Matching and Local Spatial Alignments of Ligand Binding SitesAutomated identification of protein binding surfaces and construction of SurfaceShapeSignatures ( SSS ). The nicotinamide-adenine-dinucleotide phosphate (NADP) binding surface from human pathogen S. pyogenes (PDB:2ahr, a) is defined by measuring the change in solvent accessibility between the bound and apo structure (b, pink). The SSS of a binding surface is constructed by measuring the inter-atomic Euclidean distances between all unique surface atom pairs (c). The signatures of select DNA, ligand and metal binding surfaces for proteins in the PDB.Back to article page