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Figure 10 | BMC Structural Biology

Figure 10

From: Protein Functional Surfaces: Global Shape Matching and Local Spatial Alignments of Ligand Binding Sites

Figure 10

Retrieval of ATP binding proteins from functionally and conformationally diverse classes. Binding surfaces representing different ATP conformational classes: cAMP- dependent kinase (PDB:1atp, a), protein kinase CK2 from Z. Mays (PDB:1a6o, b), ATP:corrinoid adenosyltransferase from S. typhimurium (PDB:1g5t, c), PurT-encoded glycinamide ribonucleotide transformylase from E. coli (PDB:1kj8, d). A superposition of the molecules from each class (f). The retrieval rate for each binding surface against the GPSS library is shown as an ROC plot in (e). The retrieval rates are calculated using the SurfaceScreen score.

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