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Figure 11 | BMC Structural Biology

Figure 11

From: Protein Functional Surfaces: Global Shape Matching and Local Spatial Alignments of Ligand Binding Sites

Figure 11

Crystallographic validation of GDP binding prediction in structural genomics target. The strong similarity of the putative binding surface of F420-0:gamma-glutamyl ligase homolog from A. fuldgidus[56] (a) to the GDP binding surface in GDP-binding protein from B. taurus (Figure 3c) allows a GDP molecule (red, colored by element) to be posed into the surface based on the surface superposition. The structure was determined with bound GDP (green, colored by element) with RMSD of 1.0Ǻ from predicted position (b). The addition of the ligand to the crystallization conditions improved the quality of the structure from 2.5Ǻ (a, gray) to 1.35Ǻ (a, green) and allows loop regions (magenta) to be modeled.

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