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Figure 14 | BMC Structural Biology

Figure 14

From: Protein Functional Surfaces: Global Shape Matching and Local Spatial Alignments of Ligand Binding Sites

Figure 14

An all-against-all comparison of ATP binding surfaces in the PDB. The dendrogram represents the results of complete-linkage clustering, applied to SurfaceScreen score between all surfaces in our dataset (a). The nodes of the dendrogram are color coded for kinase families according to KinBase nomenclature. A branch of the cluster (gray box) is called-out to highlight the unexpected similarity discovered between the STI-571 binding site in c-Abl kinase and serine/threonine kinase p38 MAP (b).

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