Figure 9

Binding surface-based classification of structural homologs. Putative binding surfaces for structural genomics targets with structural homology to IsdG (PDB:1xbw) and IsdI (PDB:1sqe) from S. aureus are clustered by SurfaceScreen scores. The heme binding pocket is well conserved in protein TT1390 from T. thermopilus (PDB:1iuj) and protein BC2969 from B. cereus (PDB:1tz0). ActVA-Orf66 from S. coelicolor (PDB:1lq9), is known to bind 6-deoxydihydrokalafungin (6-DHHK)[51]. Cofactors are shown immediately below each protein.