Figure 2

NMR data summary for lin-McoTI. Data on sequential and medium range NOE connectivities, ³J_HN-Hαcoupling constants and slowly exchanging amide protons observed for lin-MCoTI are summarized. The height of the bars correspond to the strength of the NOEs. The values of the ³J_HN-Hαcoupling constants are indicated by ↓ (< 4 Hz) and ↑ (> 8.5 Hz). Open and filled squares indicate backbone amide protons that were still observed after 3 and 24 h, respectively, in ²H₂O. The deviations from random coil values for the ¹³C chemical shifts of Cα of lin-MCoTI are plotted at the bottom of the figure.