Figure 1

Distributions of positional rank-correlations with global structural change for six superfamilies. Histograms of Spearman's rank correlation coefficients with bin widths of 0.05 for the six datasets (dashed black lines). Partial correlations controlled for global sequence-structure similarity are also plotted (solid red lines). Datasets are ordered left-to-right: amylase, cupredoxin, globin, lysozyme, viral capsid (jellyroll), phospholipase A₂ (snake venom toxin).