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Table 4 Associations between structural correlations and residue types

From: An automatic method for assessing structural importance of amino acid positions

AA

Chi-sq.

Significance

N

Category

A

36.7

< 4e-15

3339

Uninformative

C

137.6

< 4e-15

982

Informative

D

48.5

< 5e-10

2373

Neutral

E

58.3

< 4e-12

1934

Uninformative

F

93

< 4e-15

1621

Uninformative

G

33.9

< 4e-15

2830

Informative

H

7.4

> 0.05

1098

Not Significant

I

8.4

> 0.05

1729

Not Significant

K

29.1

< 1e-05

2369

Uninformative

L

52.8

< 1e-10

2812

Informative

M

9

> 0.05

762

Not significant

N

30

< 1e-05

1963

Uninformative

P

49.9

< 1e-10

1540

Informative

Q

12.9

< 0.025

1181

Uninformative

R

37.5

< 2e-07

1419

Uninformative

S

11.6

> 0.05

2172

Not Significant

T

0.6

> 0.05

1926

Not significant

V

21.1

< 1e-03

2441

Neutral

W

38.8

< 1e-07

745

Informative

Y

17.3

< 0.005

1625

Informative

  1. Chi-squared (chi-sq) values with significance levels for structural correlations (see Methods) are shown for each of the twenty amino-acid types. Significance values are corrected for twenty tests using Bonferroni's correction. The "category" column indicates the direction of correlation overrepresented for that class where probabilities were significant at the 5% level.