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Table 6 Crystallographic statistics for an MK2/lead compound inhibitor complex.

From: Rational mutagenesis to support structure-based drug design: MAPKAP kinase 2 as a case study

Parameter

Value

Construct

MK2(47–366, T222E)

Crystal form

IV

Space group

F 4132

Resolution (Ã…)

20.0–2.9

Unit cell length (a; Ã…)

253.508

Unique reflections

29,178

Rsym

0.069

⟨ I/σ I  ⟩

10.9

Data completeness (%)

99.7

Mean multiplicity

8.2

Rcryst (%)

22.9

Rfree (%)

26.8