Context dependent reference states of solvent accessibility derived from native protein structures and assessed by predictability analysis

Table 2 Frequency of residues in Ala-X-Ala conformations, their extended state ASA (ESA) values and highest observed ASA (HOA) obtained from the entire data set of proteins (8.9 million residues, overall including residues with different sequence neighbors).

Correlation coefficient (CC) between relative ASA obtained after normalizing by the Ala-X-Ala extended state (ESA) and tripeptide highest observed ASA (context-dependent ASA) is also provided in the last column. CC values are based on all residues with different sequence neighbor. Residues are arranged in the order of CC values.
Abbreviations: Res: residue ID, Freq: number of residues in Ala-X-Ala conformation, ESA: extended state ASA of Ala-X-Ala conformation, HOA: highest observed ASA in Y-X-Z conformation (any neighbor), CC: correlation coefficient between ESA-normalized and HOA-normalized values in the benchmark data set.

ISSN: 1472-6807