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Table 4 Comparison of the prediction performance obtained by using ESA- and HOA-normalized target ASA values.

From: Context dependent reference states of solvent accessibility derived from native protein structures and assessed by predictability analysis

Res. Freq MAE CC     P-values
   Rel (ESA) (%) Rel (HOA) (%) Abs (ESA) (Å2) Abs (HOA) (Å2) Rel (ESA) Rel (HOA) Abs (ESA) Abs (HOA) t-test u-test
A 30972 14.81 14.13 16.22 15.64 0.63 0.65 0.63 0.66 0.002 5.0e-10
C 5156 10.39 13.28 14.53 12.25 0.33 0.35 0.33 0.37 8.39e-13 0
D 22482 21.04 17.30 30.31 29.73 0.49 0.50 0.49 0.52 0.018 0.579
E 25303 20.09 17.00 35.11 34.12 0.49 0.50 0.49 0.52 5.21e-04 0.027
F 15016 11.60 11.63 23.22 21.71 0.40 0.44 0.40 0.45 7.28e-06 0
G 27935 20.25 17.60 15.31 15.90 0.51 0.52 0.50 0.54 0.621 2.3e-4
H 8596 16.22 16.36 29.50 29.28 0.54 0.55 0.54 0.56 0.825 0.581
I 21345 10.80 11.21 20.05 17.55 0.46 0.50 0.46 0.50 2.79e-13 0
K 21997 17.82 17.46 36.64 36.97 0.43 0.43 0.43 0.45 0.015 0.008
L 34119 11.40 11.27 20.86 19.34 0.47 0.51 0.47 0.51 1.58e-12 0
M 8130 12.20 12.99 24.40 21.84 0.48 0.52 0.48 0.53 3.44e-10 0
N 16660 20.87 17.63 30.55 30.38 0.53 0.52 0.53 0.54 0.621 0.148
P 17214 17.96 18.39 25.47 25.23 0.52 0.53 0.52 0.54 0.514 0.426
Q 14334 18.73 17.21 33.46 33.31 0.52 0.52 0.52 0.53 0.993 0.194
R 18302 17.57 16.21 40.23 39.85 0.46 0.46 0.46 0.47 0.243 0.647
S 22408 18.62 16.48 21.83 21.64 0.56 0.57 0.56 0.58 0.944 0.092
T 20973 16.71 15.61 23.17 22.97 0.56 0.58 0.56 0.58 0.710 0.343
V 26399 11.72 11.69 18.04 16.56 0.52 0.55 0.51 0.55 0.000 0
W 5625 11.77 13.80 28.35 26.76 0.36 0.37 0.36 0.38 0.008 9.93e-7
Y 13636 13.24 13.45 28.29 27.73 0.42 0.43 0.42 0.43 0.110 0.040
  1. Abbreviations: Res: Residue ID, MAE: mean absolute error in prediction measured in percentage points, CC: Correlation coefficient, Rel: relative ASA values, Abs: using absolute area units, t-test: Student's t-test statistics, u-test: Mann-Whitney u-test