Schematic illustration of the DICHOT system. Structural domain and ID region assignments by different methods are presented at the top, the status boxes are displayed in the middle to illustrate the classifications after the corresponding steps, and a flow chart is shown in the lower half. Data processing proceeds from left to right. In the upper-most four rows, results of trans-membrane assignments, structural domain (SD) searches, DISOPRED2 prediction, and CLADIST prediction of a hypothetical query sequence are depicted, with the vertical dotted lines marking the N- and C- termini of the query. The blue, green, and purple bars respectively represent a trans-membrane region, regions structurally aligned by homology searches, and ID regions predicted by DISOPRED2, while the alternating purple and light green segments signify the ID regions and structural domains predicted by CLADIST, respectively. The red and gray bars stand for known domains and ID regions, respectively, while the orange section denotes a cryptic domain.