Figure 1

Example of sequence/structure domain disagreement due to difference in concept. The structure of ABL1 tyrosine kinase (PDB id: 2FO0, chain A) and the sequence domains SH3, SH2, and tyrosine kinase C-terminal region (CDD ids: cd00174, cd00173, cd00192). Structure based domains shown as cartoons in purple, blue, brown and light green. Sequence based C-terminal tyrosine kinase domain shown in red, SH3 shown in dark green, SH2 shown in yellow represented as thick backbone trace. The schematic of domain arrangement shows full protein chain, structure domains 1 through 4, and the three sequence domains.