Figure 8
From: On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF
A model of autoinhibition and activation of PDZRhoGEF. In the inhibited protein the linker between the RGSL and DH domains is sequestered by the two modules, and the DH domain is not accessible to RhoA. Interaction with the Gα subunit, and possibly direct interaction with relevant GPCRs via the PDZ domain, relieve this inhibition by first dislodging the RGSL domain and then the inhibitory portion of the linker.