Figure 2

Various quaternary associations of hot dog fold proteins. D – dimer (PDB code: 1MKA); dh – double hot dog (PDB code: 1C8U); H1 – hexamer with active site loops at interface (PDB code: 1Z6B); H2 – hexamer with N-terminal helices at interface (PDB code: 1YLI); H3 – hexamer with head-to-tail arrangement of dimers (PDB code: 2PFC); TA – tetramer with central helix interactions (PDB code: 1BVQ); TB – tetramer with back to back stacking of the β-sheets (PDB code: 1Q4T). D_dhA (dimer of double hot dog with central helix interactions) is similar to TA while D_dhB (dimer of double hot dogs with back to back interaction of the β-sheets) is similar to TB. Tr_dh (trimer of double hot dogs) is similar to H2.