Figure 1

Structure of open and closed BCL. The open and closed conformation of BCL is shown in a cartoon representation. The lid of the open crystal structure of BCL [PDB: 3LIP] is colored blue and of the closed homology model green, the sphere of the Ca²⁺-ion is colored yellow. The catalytic triad consisting of Ser, His, and Asp is colored red. For analysis distances were measured between atom C_α of residue 132 from the simulated to the initial structure, respectively.